Hypergeometric test for gene list overlap — hypergeometric_test_for

Tests whether the overlap between two gene lists is statistically significant. It answers the question: given a background set of genes (global), a reference gene set (base_list), and a test gene set (test_list), is the overlap between test_list and base_list more than expected by chance?

Usage

hypergeometric_test_for_twolists(
  test_list,
  base_list,
  global,
  lower.tail = FALSE
)

Arguments

test_list: Character vector. The test gene list.
base_list: Character vector. The reference gene list.
global: Character vector. The background gene set.
lower.tail: Logical. If FALSE (default), calculates the probability of observing greater than or equal to the observed overlap (enrichment). If TRUE, calculates the probability of observing less than or equal to the observed overlap (depletion).

Value

Numeric p-value.